/https://siu.edu/search-results.php
Last Updated: Mar 25, 2026, 04:21 PM
Effective Date: August 12, 2022.
The purpose of this document is to describe available options and next steps for transferring the duties and responsibilities of the approved Principal Investigator (PI) to a new PI.
Investigator: The HHS regulations at 45 CFR part 46 use the term “investigator” to refer to an individual performing various tasks related to the conduct of human subjects research activities, such as obtaining informed consent from subjects, interacting with subjects, and communicating with the IRB.
Principal Investigator (PI): One investigator is designated the “principal investigator” with overall responsibilities for the study.
When a PI on a Southern Illinois University Carbondale approved IRB protocol relinquishes affiliation with the university the PI no longer has this institution’s approval to continue their study and must either identify a new PI who will accept responsibility for the study in its entirety, including those actions taken before assuming the role of the PI, or close the study.
When transferring PI responsibility to a new PI, the following is required:
The study may also be closed rather than transferred to a new PI. Please see the IRB website and file the Protocol Close-Out Form (a fillable pdf).
Additional considerations may apply for grant funded projects. Questions regarding how the transfer of an IRB protocol might impact a grant should be directed to the Office of Sponsored Projects.